Actin scaffold describes cell nucleus to get out of cancer cells

Cancer cells are subject to excessive mechanical pressure, which leads to the breakdown of the nuclear envelope by migrating through narrow tissue structures as in the case of metastasis.DNA is usually filtered in this process, causing damage to the cell.The protection process comes into effect at this time.

O Actin Andenging Actin explains to survival of cancer cells

The high mechanical stress is under high mechanical pressure that leads to the structure of a nuclear lifting structure while regular tissue structures, such as the metasis.NNNN usually hurt the process and harms the cell in the process.

Fine scaffolding of actin fillam formed in the second cell killlet.Remove and eliminate DNA-Clouds.

"This protection mechanism gives an explanation that you can continue to migrate despite the high mechanical pressure and cancer cells do not die." See Grocilajic instead of published in Embo Jernal.

Highest performance microscopy and cells in cells

For this study, the researchers have deployed a high invasive cancer cell (HT1080 cells) in 3 or 8 micrometer micromemism Cannons.Special narrow cross crossing causes nuclear rupture.Actin segments are formed in about 80 seconds such broken.

The team named Nuclear Force Microscopy, named Mechanical Properties of Cell News. With Pitner, a supporting partner worked in the cluster to trigger to trigger the formation of the exploration of Explorer.

Meter and value of medical purposes

Researchers were able to demonstrate proteins Diaff 3 and DNA damage to the ATR sensor protein for the protective procedure.When scientists blocked the procedure, the cell nucleus became unstable, and most of the DNA leaked.

"It has been a long time, ATRRAN ATR-FAIN's target can be used to take care of the defense system.

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